The Surprisingly Positive Association Between Obesity and Cancer Immunotherapy Efficacy

Of all the physiological parameters affecting human health, few have generated such an overwhelming consensus of adverse effects as obesity (typically defined as having a body mass index [BMI] ≥30). The incidence of obesity has been steadily rising in developed countries, reaching pandemic proportions, with a prevalence of more than 39% in the United States and continuing to increase.¹ It is therefore critical to understand the potential effects of obesity on disease incidence and progression and on treatment outcomes.