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Evolving Issues in Oncology
March 18, 2019

The Surprisingly Positive Association Between Obesity and Cancer Immunotherapy Efficacy

Author Affiliations
  • 1Department of Dermatology, University of California Davis School of Medicine, Sacramento
  • 2Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento
  • 3Department of Medicine, Harvard Medical School, Boston, Massachusetts
JAMA. 2019;321(13):1247-1248. doi:10.1001/jama.2019.0463

Of all the physiological parameters affecting human health, few have generated such an overwhelming consensus of adverse effects as obesity (typically defined as having a body mass index [BMI] ≥30). The incidence of obesity has been steadily rising in developed countries, reaching pandemic proportions, with a prevalence of more than 39% in the United States and continuing to increase.1 It is therefore critical to understand the potential effects of obesity on disease incidence and progression and on treatment outcomes.

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