In Reply In response to the comments of Dr de Kouchkovsky and colleagues, we estimated the cumulative incidence of CVD events and all-cause mortality using unadjusted Cox regression models (Figure, A and C) and models that included adjustment for age, sex, race, study site, education level, body mass index, smoking status, physical activity, total cholesterol, high-density lipoprotein cholesterol, and fasting glucose (Figure, B and D). Consistent with the results in the original article,1 the cumulative incidence of CVD events and all-cause mortality associated with stage 2 hypertension was lower in the adjusted compared with unadjusted models. However, the cumulative incidence remained 4 times higher among participants with stage 2 hypertension vs their counterparts with normal blood pressure.
Yano Y, Muntner P, Lloyd-Jones D. Hypertension in Young Adults and Subsequent Cardiovascular Disease—Reply. JAMA. 2019;321(13):1310–1311. doi:10.1001/jama.2019.0065
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