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Comment & Response
April 2, 2019

Hypertension in Young Adults and Subsequent Cardiovascular Disease—Reply

Author Affiliations
  • 1Department of Community and Family Medicine, Duke University, Durham, North Carolina
  • 2Department of Epidemiology, University of Alabama at Birmingham
  • 3Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA. 2019;321(13):1310-1311. doi:10.1001/jama.2019.0065

In Reply In response to the comments of Dr de Kouchkovsky and colleagues, we estimated the cumulative incidence of CVD events and all-cause mortality using unadjusted Cox regression models (Figure, A and C) and models that included adjustment for age, sex, race, study site, education level, body mass index, smoking status, physical activity, total cholesterol, high-density lipoprotein cholesterol, and fasting glucose (Figure, B and D). Consistent with the results in the original article,1 the cumulative incidence of CVD events and all-cause mortality associated with stage 2 hypertension was lower in the adjusted compared with unadjusted models. However, the cumulative incidence remained 4 times higher among participants with stage 2 hypertension vs their counterparts with normal blood pressure.