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February 17, 1945


JAMA. 1945;127(7):398-399. doi:10.1001/jama.1945.02860070030011

Folley and Malpress,1 working at the National Institute for Research in Dairying, University of Reading, in England under a research grant from the Agricultural Research Council, were able to induce lactation in nulliparous heifers and dry cows by the subcutaneous implantation of large numbers of small tablets of diethylstilbestrol or hexestrol. Individual variations and responses were large, but in some cases the lactation curve was comparable with that of normal lactation. The best response was obtained with a dry cow which gave a maximum yield of 30 1/4 pounds daily and a total yield of 7,400 pounds. Implants totaling 5 and 2.5 Gm. were equally effective and there appeared to be no difference in efficacy between diethylstilbestrol and hexestrol. Copious lactation was also induced in nulliparous heifers and dry cows by the subcutaneous implants of one or two tablets of hexestrol weighing approximately 1,000 mg.

The estrogen treatment was