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Biotech Innovations
April 9, 2019

HIV Remission After Hematopoietic Stem Cell Transplant

JAMA. 2019;321(14):1343. doi:10.1001/jama.2019.3460

In a historic case, a patient in London achieved sustained HIV remission after receiving an allogeneic hematopoietic stem cell transplant (HSCT) for Hodgkin lymphoma. The report, published in Nature, comes more than a decade after the now-famous “Berlin patient,” Timothy Ray Brown, was cured of HIV after 2 allogeneic HSCTs for acute myeloid leukemia. Both patients received cells from donors with a mutation in the CCR5 gene that provides resistance to HIV. Since Brown, no other successful cases of sustained HIV remission after stem cell transplantation have been reported.

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