Over the past 30 years, extensive research has explored the use of nutritional supplements for prevention of cancer. Despite what appears to be strong observational evidence, randomized clinical trials of beta carotene, ascorbic acid, alpha tocopherol, selenium, and folic acid all failed to show evidence of efficacy for cancer chemoprevention.1,2 The colorectum has been particularly well studied: trials of these interventions examining adenoma recurrence have been uniformly negative as well.3,4
Barry EL, Passarelli MN, Baron JA. Vitamin D as Cancer Therapy? Insights From 2 New Trials. JAMA. 2019;321(14):1354–1355. doi:10.1001/jama.2019.2589
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