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April 9, 2019

Vitamin D as Cancer Therapy?Insights From 2 New Trials

Author Affiliations
  • 1Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire
  • 2Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill
JAMA. 2019;321(14):1354-1355. doi:10.1001/jama.2019.2589

Over the past 30 years, extensive research has explored the use of nutritional supplements for prevention of cancer. Despite what appears to be strong observational evidence, randomized clinical trials of beta carotene, ascorbic acid, alpha tocopherol, selenium, and folic acid all failed to show evidence of efficacy for cancer chemoprevention.1,2 The colorectum has been particularly well studied: trials of these interventions examining adenoma recurrence have been uniformly negative as well.3,4