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February 24, 1945

PRESENT STATUS OF CHRONIC REGIONAL OR CICATRIZING ENTERITIS

JAMA. 1945;127(8):449-456. doi:10.1001/jama.1945.02860080021006
Abstract

Consummative treatment of any disease comprises the destruction of the causative agent and/or the complete removal of the resultant lesion when one exists. Obviously this situation does not maintain in chronic regional enteritis. A definitive etiologic factor has not been discovered and often the entire lesion, particularly in the mesentery, cannot be removed with safety. Furthermore, after wide surgical excision of the diseased segment of intestine and its mesentery recurrences frequently take place. Sufficient experience has accrued since the epochal contribution of Crohn, Ginzburg and Oppenheimer1 in 1932 to justify an appraisal of the present state of our knowledge of this interesting and not too rare lesion of the intestine.

NONCONTROVERSIAL ASPECTS OF CHRONIC ENTERITIS  It is not difficult to prepare a ledger epitomizing our present knowledge of this disease and the degree of success which has been had in the management of it. There is general agreement concerning

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