The theory of maternal immunization to the Rh factor as the primary etiologic agent in the production of erythroblastosis has become widely accepted in the last few years. Clinical observations are in remarkably close agreement with the findings which are to be expected on the basis of the theory, and although part of the actual mechanism by which the disease is produced is still unknown the basic facts must be considered as established. The following conditions should exist if the theory is correct:
1. The mother is Rh negative.
2. The father is Rh positive.
3. The fetus is Rh positive, the Rh positive gene being inherited as a mendelian dominant.
4. The Rh factor passes from the fetus to the mother. The mode of transmission has not been proved but is presumed to be by passage of Rh positive fetal erythrocytes from the fetal to the maternal circulation.
Potter EL, Willson JR. ARTIFICIAL INSEMINATION AS A MEANS OF PREVENTING ERYTHROBLASTOSIS. JAMA. 1945;127(8):458–459. doi:10.1001/jama.1945.92860080001008
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