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Comment & Response
April 16, 2019

Evaluation for Fibrosis After Cure of Hepatitis C—Reply

Author Affiliations
  • 1Division of Gastroenterology, Duke University Health System, Durham, North Carolina
  • 2Durham Veterans Affairs Medical Center, Durham, North Carolina
JAMA. 2019;321(15):1535. doi:10.1001/jama.2019.0873

In Reply Dr Fischer and colleagues highlight 2 important points regarding the decision to perform VCTE.1 We agree that specificity describes the accuracy of a test in the absence of disease and defines the ability of a test to correctly classify an individual as disease free. We obtained our information regarding 94% specificity of VCTE to rule out cirrhosis from the study by Cardoso et al.2 Accuracy of VCTE was evaluated in patients with hepatitis B and HCV in whom the presence of cirrhosis was unknown. In their analysis, VCTE was 94% specific in individuals without cirrhosis and an LSM less than 12.5 kPa. The intent of our sentence was to indicate the accuracy of the test and probably should not have used the word specific given the interpretation that this would mean specificity. We have asked that the article be corrected online. We apologize for any confusion.