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February 24, 1945

METATHYROID-ALLOXAN DIABETES

JAMA. 1945;127(8):482. doi:10.1001/jama.1945.02860080054021

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Abstract

To the Editor:—  De Finis and Houssay (Tiroides y diabetes en el perro, Rev. Soc. argent. de biol.19:94 [June] 1943) found that: 1. The administration of 0.5 Gm. of thyroid powder per kilogram of body weight to normal dogs does not produce diabetes. 2. The same treatment may produce diabetes in dogs with the pancreas reduced to one fifth or less in size by previous operation but with normal glycemia up to the thyroid administration. 3. The thyroid induced diabetes may last not more than the thyroid treatment (thyroid type) or be a permanent one (metathyroid type). 4. Treatment with thyroid may also produce diabetes in dogs with a pancreas otherwise injured by previous treatment with extracts of the anterior hypophysis. According to the Buenos Aires letter in your issue of Dec. 11, 1944 these facts have been insisted on in a recent lecture by Dr. Houssay, who

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