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February 24, 1945

Sulphonamides in the Treatment of Meningococcal Meningitis

JAMA. 1945;127(8):493. doi:10.1001/jama.1945.02860080065030

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In this pamphlet is presented a study of 2,223 cases of meningococcic meningitis observed in Scotland from 1936 to 1941. The figure stated represents about 40 per cent of all reported cases. Statistics show the effects of different methods of treatment, and comparisons are made in fatality rates before and since the introduction of chemotherapy. The authors believe that antitoxin or serum in combination with the sulfonamides does not promote therapeutic efficiency. However, this view is based apparently on the theory that, with the combined method, antitoxin or serum would be administered intrathecally. No definite preference is expressed for any one of the three sulfonamides used. Most of the patients received sulfapyridine, and the fatality rate for these was 17.17 per cent. For smaller groups the sulfanilamide rate was 9.37 and for sulfathiazole 14.6. The rate with serum or antitoxin alone was 51.76, but presumably these patients were treated intrathecally—not

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