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March 3, 1945


JAMA. 1945;127(9):517-518. doi:10.1001/jama.1945.02860090023006

The indications for chemotherapy with the sulfonamides and penicillin may be divided into those which are well established through common and consistent experience and those concerning which there is uncertainty either because of conflicting results recorded in the literature or because experience is still too limited or uncontrolled to provide a definite conclusion.

Because of the limitations of time I shall confine my remarks largely to the positive indications for the use of the sulfonamides and penicillin, avoiding discussion of debatable territory and the long list of virus, bacterial, mycotic, rickettsial and other infections in which neither the currently available sulfonamides nor penicillin are indicated.

The first and most important indication is the etiology of the infection in the patient to be treated. Factors which may modify this indication and the choice of drug to be used are the site of the infection, the nature of the pathologic process, the

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