The experimental demonstration by Abelous and Bardier in 1909 that urine contains a "hypotensive" substance gave impetus to a search for tissue extracts in treatment of hypertensive and myospastic states. Two products in particular received particular acclaim both here and abroad as effective antispasmodics. The two products, known as depropanex and padutin, are pancreatic extracts free from insulin, histamine and choline. A number of clinical reports emphasize their effective ness in the treatment of intermittent claudication, ureteral colic, angina pectoris, dysmenorrhea and peripheral arterial disease. The benefits obtained were credited to a supposed antispasmodic action associated with direct relaxation of smooth muscles in the blood vessels, ureter or uterus. These extracts were administered orally or intramuscularly, and intravenous injections were considered capable of harm.
Dreisbach and his associates1 performed careful laboratory experiments to determine the antispasmodic action, if any, of these extracts on the smooth muscles, subjecting circular muscles
ANTISPASMODIC ACTION OF "HYPOTENSIVE" EXTRACTS ON SMOOTH MUSCLES. JAMA. 1945;127(9):522. doi:10.1001/jama.1945.02860090028009
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