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The authors of this book are definitely committed to the view that so-called essential human hypertension is not primarily of renal origin. They believe that the initial cause of this type of hypertension is some unknown humoral agent which brings about the generalized vasospasm that determine the elevation of blood pressure. The organic vascular disease, including the intrarenal and generalized arteriolosclerosjs so frequently found in association with essential hypertension, they consider to be secondary to the same humoral mechanism that initiates the hypertension. They admit that even in man hypertension may be of renal origin, but only when the renal disease is known to be primary. The renal vascular disease of essential hypertension they do not regard as primary. The various arguments, including the evidence presented by the recent work on experimental renal hypertension, now adduced in favor of the primary renal origin of human hypertension, fails to convince these
Hypertension and Hypertensive Disease. JAMA. 1945;127(9):554. doi:10.1001/jama.1945.02860090060026
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