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May 7, 2019

Fever Induces a Molecular Homing Response in Immune Cells During Infection

JAMA. 2019;321(17):1657-1658. doi:10.1001/jama.2019.4475

Fever is a conserved response that is important for survival during infection and injury, and even cold-blooded animals raise their core temperature when infected with bacteria by seeking warmer environments despite the risk of predation. The mechanisms that account for the physiological benefits of a metabolically expensive phenomenon such as fever are only partially understood. Now, a recent study in Immunity suggests that fever promotes T lymphocyte homing to sites of infection by altering their surface proteins.

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