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March 10, 1945


JAMA. 1945;127(10):594. doi:10.1001/jama.1945.02860100038012

Penicillin injected intramuscularly or intravenously is rapidly excreted in the urine, an effective therapeutic level in the blood stream rarely being maintained for as long as two hours after injection. In order to prolong the effective concentration in the blood clinicians repeat the intramuscular or intravenous dose at three to four hour intervals or resort to some method of continuous instillation.1 Several alternate methods of prolonging penicillin action have been suggested by recent experimenters, such as the simultaneous injection of diodrast2 or para-aminohippuric acid,3 both of which retard the rate of renal excretion of penicillin. Others have suggested suspending the intramuscular dose in oil or in oil containing 0.75 to 6 per cent of beeswax4 or of reducing the rate of local absorption by prolonged chilling of the injected muscle5 or by adding epinephrine to the penicillin dose.6 Two of these methods have apparently