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Comment & Response
May 7, 2019

Prophylactic Hypothermia for Severe Traumatic Brain Injury—Reply

Author Affiliations
  • 1Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia
JAMA. 2019;321(17):1726. doi:10.1001/jama.2019.1538

In Reply In relation to the Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury (POLAR) randomized trial,1 Dr Engrand and colleagues note that neither brain oxygenation nor cerebral blood flow was measured, and patients with severe TBI in either study group may have had silent decreased brain oxygenation. Although this is possible, it is unknown because brain tissue oxygen monitoring is not recommended in current guidelines2 and was not standard practice in any intensive care unit in Australia or New Zealand at the time.