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Comment & Response
May 14, 2019

Acute Kidney Injury Related to Sepsis

Author Affiliations
  • 1Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut
JAMA. 2019;321(18):1828. doi:10.1001/jama.2019.2044

To the Editor A JAMA Diagnostic Test Interpretation article addressed the test characteristics of serum creatinine in critically ill patients with sepsis.1 The authors presented a patient with pneumonia and septic shock who developed acute kidney injury (AKI) on day 3. They discussed serum creatinine as a marker of glomerular filtration rate (GFR), noting the deficiencies of the test in patients who have received significant volume resuscitation. They noted that the biomarkers of kidney injury do not directly measure GFR, but neither does serum creatinine.