In Reply Dr Frat and colleagues suggest that a high proportion of patients died without being intubated. As mentioned in the article,1 at randomization, 4 patients had do-not-resuscitate orders and 28 had do-not-intubate orders. All other patients, including those in time-limited trials, underwent unrestricted management for at least the first ICU days. This proportion of end-of-life decisions is in agreement with previously published studies in the same population2 as well as in unselected patients admitted to the ICU to receive noninvasive ventilation for acute respiratory failure.3
Azoulay E, Chevret S, Demoule A. High-Flow Oxygen Therapy for Respiratory Failure in Immunocompromised Patients—Reply. JAMA. 2019;321(18):1827. doi:10.1001/jama.2019.2064
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