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October 24, 1936

THE TAKATA-ARA TEST AND ITS RELATION TO CIRRHOSIS OF THE LIVER

Author Affiliations

NEW YORK

From the Department of Internal Medicine, Yale University Medical School and the New Haven Hospital, New Haven, Conn.

JAMA. 1936;107(17):1354-1357. doi:10.1001/jama.1936.02770430004002
Abstract

Clinicians everywhere are anxiously and hopefully awaiting a liver function test that will be of definite diagnostic value. The recent appearance of several American papers on a new test of liver function, the Takata-Ara test, in which it was concluded that a distinct differentiation, on the basis of this test, could be made between carcinoma and cirrhosis ofthe liver, stimulated the present investigation.

This reaction was originally described by Takata,1 who used it to differentiate lobar pneumonia from bronchopneumonia. He found that when fluid from the chest of a patient with lobar pneumonia was added to a solution of sodium carbonate, mercury bichloride and acid fuchsin, a precipitate of mercury oxysol occurred. He believed that this precipitate was due to decreased stability of the serum proteins, produced essentially by an increase in the globulin fraction. Later Takata in collaboration with Ara2 reported on the reaction in cerebrospinal fluid. It

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