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March 17, 1945

SULFADIAZINE IN PREVENTION OF MENINGITIS

JAMA. 1945;127(11):673. doi:10.1001/jama.1945.02860110053022

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Abstract

To the Editor:—  It may be of interest, particularly to physicians in mental hospitals, to be informed of a situation which developed at this institution, and the procedure adopted.On Nov. 12, 1944 a man aged 33 whose mental diagnosis was psychosis with organic changes of the central nervous system, paralysis agitans, was given a clinical diagnosis of cerebrospinal meningococcic meningitis, which was directly confirmed by laboratory examinations. Penicillin was given intrathecally, with definite improvement manifest the following day, and he made a prompt and uncomplicated recovery, receiving two subsequent doses of penicillin.The point of interest is this: The patient was located in a very crowded ward. It seemed inevitable that many of the 400 patients and personnel in this ward had been exposed. Following the technic described in an article by Lieut. Col. Joseph F. Painton, M. C., U. S. Army, published in the October 1944 issue of

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