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March 17, 1945


JAMA. 1945;127(11):673. doi:10.1001/jama.1945.02860110053023

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To the Editor:—  In a recent editorial (The Journal, February 10, p. 334) commenting on British experience in the treatment of hyperthyroidism with thiouracil as reported by Nussey in the British Medical Journal, Dec. 9, 1944, it is remarked that this author has apparently presented a safe basis for continued administration of thiouracil. It is suggested that 0.6 Gm. daily of thiouracil be administered daily for three to five weeks with gradual reduction thereafter to the minimal effective dose. Adequate supervision of the patient is urged without definition of this phrase. No mention is made of any toxic reactions.Analysis of Nussey's article shows that there were 27 patients treated for periods varying from three weeks to twelve months with dosages ranging from 0.05 to 0.6 Gm. daily. Observations included leukocyte counts at intervals of one to several months. Among the 27 patients there were 4 with skin eruptions. Seven

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