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October 24, 1936

HYPOCHROMIC ANEMIA AND ALKALI THERAPY IN PEPTIC ULCER

JAMA. 1936;107(17):1391. doi:10.1001/jama.1936.02770430041015
Abstract

Loss of blood for long periods usually leads to a slow depletion of iron stored in the body and frequently to the subsequent development of a hypochromic anemia. Obviously, successful treatment of the uncomplicated anemia depends on the arrest of the hemorrhages and on the replenishment of the reserve supply of iron. One of the frequent causes of this type of anemia is the chronic loss of blood resulting from peptic ulcer. Since one of the more common methods of treatment of this disease is the use of rather large amounts of alkaline powders daily and since the utilization of iron is known to be unfavorably affected by the presence of alkali in the upper part of the gastro-intestinal tract,1 questions arise regarding the possible prolongation of periods of anemia in patients with bleeding peptic ulcer because of alkali therapy.

In a recent study at the University of California,

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