Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015 | Cancer Screening, Prevention, Control | JAMA | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Siegel  RL, Fedewa  SA, Anderson  WF,  et al.  Colorectal cancer incidence patterns in the United States, 1974-2013.  J Natl Cancer Inst. 2017;109(8). doi:10.1093/jnci/djw322PubMedGoogle Scholar
White  MC, Babcock  F, Hayes  NS,  et al.  The history and use of cancer registry data by public health cancer control programs in the United States.  Cancer. 2017;123(suppl 24):4969-4976. doi:10.1002/cncr.30905PubMedGoogle ScholarCrossref
Bailey  CE, Hu  CY, You  YN,  et al.  Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010.  JAMA Surg. 2015;150(1):17-22.PubMedGoogle ScholarCrossref
Austin  H, Henley  SJ, King  J, Richardson  LC, Eheman  C.  Changes in colorectal cancer incidence rates in young and older adults in the United States: what does it tell us about screening.  Cancer Causes Control. 2014;25(2):191-201. doi:10.1007/s10552-013-0321-yPubMedGoogle ScholarCrossref
Siegel  RL, Miller  KD, Jemal  A.  Colorectal cancer mortality rates in adults aged 20 to 54 years in the United States, 1970-2014.  JAMA. 2017;318(6):572-574. doi:10.1001/jama.2017.7630PubMedGoogle ScholarCrossref
Wolf  AMD, Fontham  ETH, Church  TR,  et al.  Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society.  CA Cancer J Clin. 2018;68(4):250-281. doi:10.3322/caac.21457PubMedGoogle ScholarCrossref
Research Letter
May 21, 2019

Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015

Author Affiliations
  • 1Stanford University School of Medicine, Stanford, California
  • 2Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands
JAMA. 2019;321(19):1933-1934. doi:10.1001/jama.2019.3076

Evidence suggests that incidence of colorectal cancer (CRC) is increasing among adults younger than 50 years in the United States.1 The underlying causes of the increased incidence are unclear. If the increase is the result of earlier detection due to increased use of colonoscopy, earlier stage at diagnosis would be expected, whereas if the increased incidence is the result of true increases in risk, relatively later stage at diagnosis would be expected. We investigated trends in CRC incidence by stage in adults younger than 50 years. We focused our study on adults aged 40 through 49 years, who account for almost 3 of 4 young-onset cases.