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Research Letter
May 21, 2019

Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015

Author Affiliations
  • 1Stanford University School of Medicine, Stanford, California
  • 2Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands
JAMA. 2019;321(19):1933-1934. doi:10.1001/jama.2019.3076

Evidence suggests that incidence of colorectal cancer (CRC) is increasing among adults younger than 50 years in the United States.1 The underlying causes of the increased incidence are unclear. If the increase is the result of earlier detection due to increased use of colonoscopy, earlier stage at diagnosis would be expected, whereas if the increased incidence is the result of true increases in risk, relatively later stage at diagnosis would be expected. We investigated trends in CRC incidence by stage in adults younger than 50 years. We focused our study on adults aged 40 through 49 years, who account for almost 3 of 4 young-onset cases.