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Comment & Response
May 21, 2019

Meta-analysis of Opioids for Chronic Pain

Author Affiliations
  • 1Department of Psychosomatic Medicine and Psychotherapy, Technische Universität München, Munich, Germany
  • 2Department of Neurology, Technische Universität München, Munich, Germany
  • 3Pain Research and Nuffield Division of Anaesthetics, University of Oxford, Oxford, England
JAMA. 2019;321(19):1934-1935. doi:10.1001/jama.2019.2177

To the Editor Dr Busse and colleagues1 analyzed the weighted mean differences of pain intensity and physical function after treatment with opioids vs placebo for chronic noncancer pain from 69 trials. However, their outcomes did not meet best practices in the reporting of systematic reviews of chronic pain trials2 and are not helpful for clinical practice.

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