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March 24, 1945


JAMA. 1945;127(12):696-699. doi:10.1001/jama.1945.02860120012003

Abdominal pain in children at times presents difficulty in diagnosis. Every year children with obscure abdominal pain are admitted to our hospital wards and subjected to many tests to rule out such conditions as tuberculous abdominal lymph nodes, various anatomic defects of the gastrointestinal tract, recurrent appendicitis, pyelitis, kidney stones and so on. Very definite causes may be found as a result of such investigations, but on occasion the child is sent home with his condition undiagnosed. Our thesis is that in some of these children abdominal pain may be due to food allergy. The many differentiating points of interpretation of abdominal pain found in intussusception, appendicitis, dysentery, peritonitis, mesenteric lymphadenopathy, pneumonia, rheumatic fever and simple gastrointestinal disturbances will not be considered in this communication. The discussion herein is solely concerned with the evaluation of abdominal pain due to food allergy.1

PATHOGENESIS  I have observed many guinea pigs with