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March 24, 1945

THE MALE CLIMACTERIC: REPORT OF FIFTY-FOUR CASES

JAMA. 1945;127(12):705-710. doi:10.1001/jama.1945.02860120021006
Abstract

Both the human male and the human female have a pituitary-gonad relationship. In the girl at puberty the anterior pituitary gonadotropic hormone stimulates the ovaries to function, with the development of a graafian follicle and the production of an ovum. The granulosa cells lining the follicle produce estrogenic hormone, which in turn stimulates development of the breasts, the internal and external genitals and the configuration of the body, which changes from that of the girl, through adolescence to womanhood.

In the boy at puberty the anterior pituitary gonadotropic hormone stimulates the testicles to function. The interstitial cells of the testicles produce androgenic hormone, which causes development of the secondary sexual characteristics and initiates the changes that develop him from boyhood through adolescence to normal manhood.

The most obvious and fundamental difference which occurs as a result of this pituitary-gonad relationship in the human male and female is the fact that

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