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Comment & Response
May 28, 2019

Fibrinolytic Therapy to Reduce Microvascular Obstruction After Myocardial Infarction

Author Affiliations
  • 1Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
JAMA. 2019;321(20):2032. doi:10.1001/jama.2019.2776

To the Editor Dr McCartney and colleagues1 evaluated the effect of a low-dose intracoronary fibrinolytic drug (alteplase) administered early after reestablishing coronary reperfusion on microvascular obstruction in patients undergoing primary percutaneous coronary intervention (PCI). Although the findings of the study did not support this mode of therapy, some aspects of the trial deserve discussion.