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Clinical Trials Update
May 28, 2019

More Folic Acid for Pregnant Smokers

JAMA. 2019;321(20):1965. doi:10.1001/jama.2019.6681

Women who smoked cigarettes during pregnancy and took higher-dose folic acid supplements delivered infants with better fetal growth than smokers who took standard-dose folic acid, according to a study published in JAMA Pediatrics.

The 345 active smokers, who were less than 21 weeks pregnant at the start of the study, were randomized to receive 4 mg of folic acid per day (higher-dose group) or 0.8 mg of folic acid per day (standard-dose group). Both groups also received smoking cessation counseling.

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