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March 24, 1945

Current Comment

JAMA. 1945;127(12):714. doi:10.1001/jama.1945.02860120030012

NODULAR PERINEURITIS AND POLYMYOSITIS IN RHEUMATOID ARTHRITIS  Freund and his co-workers1 in Detroit described distinctive inflammatory nodules in the perineurium of peripheral nerves in rheumatoid arthritis. Such lesions may occur in nerves more or less remote from affected joints as well as in nerves not connected with joints. In a study of the nerves in the amputated legs of a 27 year old woman suffering from rheumatoid arthritis, nodular lesions of a similar nature were found2 also in large numbers in the skeletal muscles. The lesions varied in size from microscopic to visible by the naked eye on stained sections of muscle. They were made up of lymphocytes, relatively few plasma cells and occasional epithelioid and eosinophilic cells, but giant cells or necrotic centers were not found. In some nodules on nerves there was a central necrosis. Such nodules were found also in biopsies of