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March 31, 1945


JAMA. 1945;127(13):757-758. doi:10.1001/jama.1945.92860130001005

Actinomycosis of the brain is a rare enough lesion to excite the interest of all medical men, regardless of their field of special interest. Such cases have usually been reported as secondary to the presence of the disease elsewhere in the body, the gastrointestinal tract being considered the most common port of entry of the ray fungus. The cerebral lesions usually described consist either of actinomycotic meningitides, of abscesses or of both. Another very rare form of cerebral actinomycosis has been described, which consists of a granulomatous tumor-like lesion with "sulfur granules" of actinomycotic colonies embedded in a gelatinous matrix. The first case of this type was reported by Bollinger1 in 1887. The patient was a woman aged 26 with symptoms of brain tumor for one year before death. At autopsy the ventricles were found to be dilated. The tumor, about the size of a large hazelnut, was