Major depressive disorder (MDD) has a lifetime incidence of 10% to 15%.1 The main treatment options include pharmacological and psychological interventions, with many patients receiving combination treatment. Although randomized clinical trials (RCTs) have established the efficacy of antidepressants,2 acute and long-term effectiveness is limited, and one-third of patients develop treatment resistance. New interventions are needed in the field and this Viewpoint examines novel interventions, with a specific focus on exercise, nutrition, and ketamine.
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Köhler-Forsberg O, Cusin C, Nierenberg AA. Evolving Issues in the Treatment of Depression. JAMA. Published online May 24, 2019321(24):2401–2402. doi:10.1001/jama.2019.4990
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