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JAMA Insights
Women's Health
May 30, 2019

Menopausal Hormone Therapy

Author Affiliations
  • 1Department of Obstetrics and Gynecology, Midlife Women’s Health Center, Massachusetts General Hospital, Harvard Medical School, Boston
  • 2Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles
  • 3JAMA Associate Editor
  • 4Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
  • 5Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts
JAMA. Published online May 30, 2019. doi:10.1001/jama.2019.5346

Hormone therapy is the most effective treatment for managing menopausal vasomotor symptoms. Hot flashes and night sweats affect approximately 70% of midlife women and may persist for a decade or longer.1 Bothersome vasomotor symptoms have a significant adverse effect on sleep, daily functioning, and quality of life. Cognitive and mood symptoms often accompany disruptive hot flashes. Although lifestyle changes and nonhormonal options are available, women with frequent, severe vasomotor symptoms may greatly benefit from hormone therapy.2

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