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Research Letter
June 11, 2019

Mortality Due to Aortic Stenosis in the United States, 2008-2017

Author Affiliations
  • 1Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio
  • 2Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio
JAMA. 2019;321(22):2236-2238. doi:10.1001/jama.2019.6292

Symptomatic severe aortic stenosis is associated with high mortality rates, up to 50% at 1 year,1 and the prevalence will likely increase as the population ages.2 Until recently, surgical valve replacement was the only durable therapeutic option; however, many older patients with aortic stenosis have prohibitive surgical risk. Transcatheter aortic valve replacement (TAVR) has emerged as an option for these patients and, more recently, for patients with high and moderate surgical risk. We identified trends in mortality due to aortic stenosis, considering these recent therapeutic advances.