To the Editor Dr Costello and colleagues assessed the efficacy of a short duration of fecal microbiota transplantation (FMT) therapy to induce remission in patients with moderately active ulcerative colitis using anaerobically prepared stool pooled from different donors compared with aerobically prepared autologous FMT. They observed a higher rate of steroid-free remission of ulcerative colitis at 8 weeks (primary outcome) for patients receiving donor FMT compared with patients treated with autologous FMT.1 The anaerobic stool preparation may allow use of a less intensive administration protocol than those described in previous studies.2 However, some biases that could overestimate the effectiveness of donor FMT need to be discussed.
Benech N, Kapel N, Sokol H. Fecal Microbiota Transplantation for Ulcerative Colitis. JAMA. 2019;321(22):2240. doi:10.1001/jama.2019.3946
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