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Comment & Response
June 11, 2019

Meta-analysis of Aspirin for Primary Prevention of Cardiovascular Events

Author Affiliations
  • 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore
JAMA. 2019;321(22):2243-2244. doi:10.1001/jama.2019.4005

To the Editor Dr Zheng and Mr Roddick1 reported frequentist and Bayesian meta-analyses examining the association between aspirin use and cardiovascular events and bleeding risk in individuals without cardiovascular disease. The investigators required randomized trials to enroll at least 1000 participants to be eligible for inclusion in the analyses. The basis for imposing such a study eligibility criteria was not explicitly justified, but a plausible motivation could be related to the perception that small randomized trials are neither adequately powered nor generalizable.