Davis1 recently reported that the administration of choline chloride orally to dogs in a dose of 10 mg. per kilogram of body weight three times a day for several months resulted in the development of a macrocytic hyperchromic anemia. The anemia responded to anti-pernicious anemia liver extract, ventriculin and atropine sulfate although the reticulocytes rose during therapy only 1.5 to 2.3 per cent. Davis advances the theory that choline depresses erythropoiesis by increasing the blood and oxygen supply to bone marrow through its vasodilator action.2
The implications of this experiment are extremely important3 and for this reason it seemed desirable to ascertain the effect of the administration of choline on the blood
Three men were used. One (E. C.), aged 47, was suffering from multiple sclerosis. The second (H. B.), aged 75, had a hemiplegia of several years' duration due to a cerebral vascular accident. The third
Cartwright GE, Wintrobe MM. EFFECT OF THE ADMINISTRATION OF CHOLINE CHLORIDE ON THE HEMATOLOGIC PICTURE IN HUMAN BEINGS. JAMA. 1945;127(14):911. doi:10.1001/jama.1945.92860140029007
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