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Research Letter
June 9, 2019

Hemoglobin A1c Levels During Pregnancy and Risk of Autism Spectrum Disorders in Offspring

Author Affiliations
  • 1Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena
  • 2Division of Endocrinology and Diabetes, University of Southern California Keck School of Medicine, Los Angeles
  • 3Obstetrics and Gynecology, Kaiser Permanente Southern California, Pasadena
JAMA. 2019;322(5):460-461. doi:10.1001/jama.2019.8584

Maternal preexisting type 1, type 2, or gestational diabetes diagnosed relatively early in pregnancy are associated with increased risk for autism spectrum disorders (ASDs) in offspring.1,2 This study extends previous observations by examining the association between maternal hemoglobin A1c (HbA1c) levels during pregnancy and risk of ASD in offspring.