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April 14, 1945

Current Comment

JAMA. 1945;127(15):991-992. doi:10.1001/jama.1945.02860150035011

PENICILLIN BY MOUTH  Simplified methods of administering penicillin that will provide adequate and prolonged blood concentrations are being sought by many investigators. Chow and McKee1 combined crystalline penicillin with human plasma proteins to make a large penicillin protein complex, which in mice is more slowly absorbed after intramuscular injection. György and his associates2 have administered penicillin orally with trisodium citrate as a buffer salt to eliminate the destructive action on penicillin by the hydrochloric acid in the stomach. Little and Lumb3 have used both the stabilizing effect of protein and the buffer action of sodium bicarbonate in administering penicillin by mouth. In doing routine penicillin sensitivity assays by the "gutter plate" method, Little and Lumb sometimes used the Seitz filtered urine of patients receiving penicillin parenterally. They noted that the urine solution seemed to retain its activity longer than the saline solution of the sodium salt of