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April 21, 1945

THE USE OF DIASONE FOR THE TREATMENT OF TUBERCULOSIS

JAMA. 1945;127(16):1043-1049. doi:10.1001/jama.1945.02860160019006
Abstract

Without becoming facetious, one could say from past evidence that tuberculosis has been the major mummer among diseases. Those who have been deceived in the past by the vagaries of this disease include such names as Brehmer by the cause of tuberculosis, Koch by tuberculin action, Virchow by the microbic origin, Behring by the source of infection, Krause by the significance of the tuberculin inflammatory reaction, and so on. The scientific investigator should be wary of the vagaries of the tubercle bacillus and tuberculosis by this time and inquire into the "whys and wherefores" of the mechanism involved before accepting mere appearances as bona fide evidence of practical actualities. In chemotherapy particularly history has recorded numerous faux pas of premature overoptimism with tuberculin, with copper, with gold, with cinnamates, with oils, with mercury, and now with the sulfonamide drugs, just to mention a few. Not that these failures should discourage

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