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April 21, 1945


JAMA. 1945;127(16):1051-1052. doi:10.1001/jama.1945.92860160002007b

The great majority of cases of subacute infectious endocarditis are caused by Streptococcus viridans. In Libman's1 series 95 per cent were due to this organism, and in the cases tabulated by Blumer2 70 per cent were due to the streptococcus, 80 per cent of these proving to be S. viridans. In the past the disease has been almost uniformly fatal. The introduction of sulfonamides and penicillin in the treatment of endocarditis has, however, unquestionably reduced the mortality rate of this disease. The following history of a patient suffering from endocarditis is interesting because of the organism producing the disease and because the patient recovered under sulfonamide therapy.

R. A., a man aged 45, admitted to the University of Kansas Hospital on Oct. 4, 1943, was somewhat confused mentally and had been ill for approximately three months, suffering from fever and "chilly sensations." In