To the Editor The DEXACET trial found a decreased incidence of postoperative delirium in older patients after cardiac surgery who received intravenous (IV) acetaminophen vs placebo combined with propofol or dexmedetomidine.1 Dr Subramaniam and colleagues suggested that the difference in the primary outcome, incidence of delirium, may have been driven in part by reduction in opioid consumption in the acetaminophen group compared with the placebo group. The reduction in opioid requirements must therefore be carefully examined.
Wanek MR. Intravenous Acetaminophen for Postoperative Delirium. JAMA. 2019;322(3):271–272. doi:10.1001/jama.2019.6130
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: