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Comment & Response
July 16, 2019

Intravenous Acetaminophen for Postoperative Delirium

Author Affiliations
  • 1Department of Pharmacy, Cleveland Clinic, Cleveland, Ohio
JAMA. 2019;322(3):271-272. doi:10.1001/jama.2019.6130

To the Editor The DEXACET trial found a decreased incidence of postoperative delirium in older patients after cardiac surgery who received intravenous (IV) acetaminophen vs placebo combined with propofol or dexmedetomidine.1 Dr Subramaniam and colleagues suggested that the difference in the primary outcome, incidence of delirium, may have been driven in part by reduction in opioid consumption in the acetaminophen group compared with the placebo group. The reduction in opioid requirements must therefore be carefully examined.