There has recently appeared in the literature an article1 in which refrigeration anesthesia in surgery is discussed from both the experimental and the clinical point of view. The character of this work on the whole is of such high grade that if all of the author's conclusions are accepted without question or challenge it will cause an unnecessary delay in the application of a therapeutic measure that has proved itself beyond any doubt to be of great value in surgery of the extremities. In the body of the paper the statement is made that "cooling per se does not seem to have a beneficial effect on an inflammatory process. While the infected part is cooled there is an inhibition not only of bacterial growth and toxin production but also of the normal tissue responce. Release from the cooling may
Kross I. LOW TEMPERATURE THERAPY FOR PRESERVATION OF LIMBS. JAMA. 1945;128(1):19–20. doi:10.1001/jama.1945.92860180001007
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