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November 21, 1936


JAMA. 1936;107(21):1739. doi:10.1001/jama.1936.02770470057020

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To the Editor:—  It is well known that many conditions can produce jaundice through an excessive destruction of erythrocytes; i. e., a "hemolytic jaundice" in the general sense. Also a clear cut hereditary disease, "chronic hemolytic jaundice with splenomegaly," has been recognized for many years, whether in the congenital form of Chauffard-Minkowski or the so-called acquired type of Hayem-Widal. This disease has unusually concise diagnostic criteria, especially the increased fragility of the erythrocytes in hypotonic salt solution, and small erythrocytes (microcytes), which tend to a more spherical form than normal. As Russell Haden has pointed out, this inherited change in form underlies the increased fragility. The disease has long been known under several, often cumbersome, names, and this is perhaps the reason it is often colloquially spoken of by the confusing, more general, term "hemolytic jaundice." Allen Whipple, for instance, has found it necessary in his Combined Spleen Clinic to

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