Individuals who enroll in clinical trials do so with the belief that their participation will help to advance medical science. However, many trials are designed, conducted, and reported in ways that stymie this objective, a problem that can be called “uninformativeness.” From the perspective of researchers, this is a form of research inefficiency.1 But from the perspective of participants, preventable uninformativeness is a serious breach of trust and a violation of research ethics.
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Zarin DA, Goodman SN, Kimmelman J. Harms From Uninformative Clinical Trials. JAMA. Published online July 25, 2019322(9):813–814. doi:10.1001/jama.2019.9892
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