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To the Editor:—
The article "Blood and Spinal Fluid Tests for Syphilis in Malarial Patients," by Harold W. Potter, Lewin H. Bronstein and Charles M. Gruber (The Journal, March 24, p. 699) is excellent evidence for the occurrence of nonspecific syphilis reactions in "natural" malaria. To make these observations completely useful, it is necessary to look at them from the opposite side too and establish the conditions under which a positive serologic reaction may be accepted with no more criticism than is always required in evaluating serotests for syphilis. The authors have not overlooked this, but more emphasis is advisable if we don't want to err by leaning back too far.The clearcut experiences on inoculated malaria, although not applicable without discernment, should facilitate orientation in the more intricate maze of natural malaria. The regular occurrence of positive syphilis reactions in nonsyphilitic persons inoculated with malaria was first described by
Brandt R. BLOOD AND SPINAL FLUID TESTS FOR SYPHILIS IN MALARIAL PATIENTS. JAMA. 1945;128(2):152. doi:10.1001/jama.1945.02860190088022
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