A consideration of the value of castration in relation to cancer of the breast is one which periodically has presented itself to the medical profession for a period of fifty-five years since its suggestion by Schinzinger in 1889. The work of Huggins in cases of cancer of the prostate has again brought up for review the subject of castration in cancer of the breast. It may be recalled in Huggins' work that the total effect of castration of the male was not obtained when castration was carried out by x-rays. He obtained his effects by surgical castration, and this is the reason for bringing up at this time a reconsideration of the subject of x-ray castration versus surgical castration.
This study represents a review of all the patients with carcinoma of the breast who have been castrated with surgery or radiation in a period of eighteen years at the Memorial
ADAIR FE, TREVES N, FARROW JH, SCHARNAGEL IM. CLINICAL EFFECTS OF SURGICAL AND X-RAY CASTRATION IN MAMMARY CANCER. JAMA. 1945;128(3):161–167. doi:10.1001/jama.1945.02860200001001
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