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May 19, 1945

THE INADEQUACY OF A STANDARDIZED DOSAGE OF PENICILLIN: IN THE TREATMENT OF GONOCOCCIC URETHRITIS

JAMA. 1945;128(3):168-170. doi:10.1001/jama.1945.02860200008002
Abstract

Reports of the efficacy of penicillin in the treatment of gonococcic urethritis have appeared. Previous studies1 of clinical trials with this type of therapy have demonstrated its curative value. Later reports2 on the rapidity of its therapeutic effect on gonococcic urethritis have further suggested that it approaches a 100 per cent clinical and bacteriologic cure. Reported failures with penicillin therapy are very rare.

The literature, to date, contains no report of a study which actually reveals the rapidity of bacteriologic cure based on serial cultures following each dose of penicillin. This study was set up to determine the exact point of bacteriologic cure within the limits of the units of penicillin used.

It has been our experience after culture study of several thousand cases of gonorrhea that clinical cure is not a definite indication of bacteriologic cure. Except in frank cases of gonococcic urethritis, smears are not a

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