The incidence of quadruplets varies in different countries. Guzzoni in 1889 published an analysis of 50,000,000 births in which quadruplets occurred once in 757,000 births. In 1895 Hellin, whose work was based on South German statistics, suggested the following easily remembered ratios: twins once in 80 births, triplets once in 80 X 80 (6,400 births and quadruplets once in 80 X 80 X 80 (512,000) births. Greulich1 published in 1930 a study of more than 120,000,000 births reported from twenty-one countries between 1915 and 1925. He found that quadruplets occurred once in 670,734 (87.53) births. According to these statistics about five sets a year should be born in the United States. The report here is of quadruplets born on Nov. 1, 1944 by cesarean section. A survey of the literature fails to reveal any previous quadruplets in which cesarean
Ullery JC. DELIVERY OF QUADRUPLETS BY CESAREAN SECTION UNDER CONTINUOUS SPINAL ANESTHESIA. JAMA. 1945;128(3):183–185. doi:10.1001/jama.1945.92860200001007a
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