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May 26, 1945

THIOURACIL TREATMENT OF ANGINA PECTORIS: RATIONALE AND RESULTS

JAMA. 1945;128(4):249-256. doi:10.1001/jama.1945.02860210005002
Abstract

Total thyroidectomy has proved an effective therapeutic procedure in the treatment of angina pectoris (Lev and Hamburger,1 Blumgart, Levine and Berlin,2 Levine and Eppinger,3 Claiborne and Hurxthal,4 Clark, Means and Sprague,5 Scherf,6 Singer7 and others).

Eppinger and Levine8 expressed the belief that the complete removal of the thyroid gland alters the response of the cardiovascular system to epinephrine and that it is the alteration of this mechanism which may, in a measure, be responsible for the relief of anginal pain. Likewise Shambaugh and Cutler9 reached the conclusion that the beneficial effect of removal of the thyroid gland in angina pectoris may be due, in a part at least, to a diminished effectiveness of the physiologic output of epinephrine. Barbour and Prince10 ascribed to epinephrine a causative role in angina pectoris as early as 1915, when they showed that it constricts

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