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December 12, 1936

THE CLINICAL USE OF DIURETICS

JAMA. 1936;107(24):1937-1941. doi:10.1001/jama.1936.02770500003002
Abstract

Diuretics are drugs used to increase the volume of urine. This presupposes the kidneys to be in such condition that the formation of urine is possible; there must be at least a certain degree of parenchymal integrity, a sufficient blood pressure and an adequate blood flow. These facts are not infrequently overlooked, and attempts are made to increase the flow of urine by diuretics when they are bound to fail. For instance, in the oliguria or anuria of surgical shock and Addison's disease, efforts to raise the blood pressure will have much more effect on urine excretion than will diuretics. In the oliguria of congestive heart failure diuretics are much more effective when the circulation has been improved by rest or by rest and digitalis. In the anuria of mercury bichloride poisoning, no diuretic will increase the excretion of urine until a certain amount of regeneration has taken place in

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